QcrB inhibitor TB47( TB47 )

Catalog No. M12724 CAS No. 1799682-71-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

QcrB inhibitor TB47
Note

Research use only, not for human use.
Brief Description

QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M.
Description

QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates; shows promising profiles, including negligible CYP450 interactions, cytotoxicity and hERG channel inhibition in pharmacokinetic and toxicity studies; causes metabolic redox stress, strongly synergistic with pyrazinamide and rifampicin in mouse infection models, but not as a monotherapy.
In Vitro

——
In Vivo

——
Synonyms

TB47
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1799682-71-5
Formula Weight

538.571
Molecular Formula

C29H29F3N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=NN2C=CC(=CC2=C1C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F)OC
Chemical Name

5-methoxy-2-methyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)pyrazolo[1,5-a]pyridine-3-carboxamide

1. Lu X, et al. ACS Infect Dis. 2018 Nov 28. doi: 10.1021/acsinfecdis.8b00225.

Calculator

molnova catalog