QcrB inhibitor TB47 ( TB47 )

Catalog No. M12724 CAS No. 1799682-71-5

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Product Name

QcrB inhibitor TB47
Note

Research use only, not for human use.
Brief Description

QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M.
Description

QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates; shows promising profiles, including negligible CYP450 interactions, cytotoxicity and hERG channel inhibition in pharmacokinetic and toxicity studies; causes metabolic redox stress, strongly synergistic with pyrazinamide and rifampicin in mouse infection models, but not as a monotherapy.
Synonyms

TB47
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1799682-71-5
Formula Weight

538.57
Molecular Formula

C29H29F3N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=NN2C=CC(=CC2=C1C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F)OC
Chemical Name

5-methoxy-2-methyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)pyrazolo[1,5-a]pyridine-3-carboxamide

1. Lu X, et al. ACS Infect Dis. 2018 Nov 28. doi: 10.1021/acsinfecdis.8b00225.

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